CFB Computer Picks, Analysis and Prediction For Syracuse vs. Clemson on October 22, 2022

In a meeting between two unbeaten ACC teams, the Syracuse Orange will be looking to pull off a shocking upset over the Clemson Tigers at 12:00PM ET on Saturday, October 22.

Will the Orange find a way to get the job done? You might want to keep reading our Syracuse vs. Clemson betting preview to find out. 

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Syracuse vs. Clemson Computer Picks

  • 78% chance Clemson wins on the moneyline
  • 53% probability Syracuse covers the +13.5 spread
  • 53% shot Syracuse vs. Clemson goes Over 49.5 total points

  
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By Dimers