Penn State vs. Michigan State odds, line, spread: Proven model reveals college football picks, predictions for Week 13, 2022

A Big Ten battle is on tap between the No. 11 Penn State Nittany Lions and the Michigan State Spartans at 4 p.m. ET on Saturday at Beaver Stadium. Michigan State has won six of the last nine matchups between these teams, but it is a heavy underdog this year. The Nittany Lions are favored by 18.5 points in the latest Penn State vs. Michigan State odds from Caesars Sportsbook, while the over/under is set at 52.5.'
  
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