The seventh-place team in the Eastern Conference, the New York Islanders (38-27-16), host the 10th-ranked Pittsburgh Penguins (38-31-12) at UBS Arena on Wednesday at 7:00 PM ET.
New York earned a 4-1 road victory against the New Jersey Devils its last time out on April 15.
Pittsburgh won its most recent game 4-2 at home over the Nashville Predators on April 15.