The 2023 MLB season begins on Thursday when the New York Yankees and San Francisco Giants collide on Opening Day at Yankee Stadium in the Bronx. The Yankees are coming off a season in which they were swept by the eventual World Series champion Astros in four games in the American League Championship Series. Meanwhile the Giants, who won 107 games in 2021, are looking to bounce back from an 81-81 season and missing the playoffs a year ago. First pitch is set for 1:05 p.m. ET.
New York is the -170 money-line favorite in the latest Yankees vs. Giants odds from Caesars Sportsbook, while San Francisco is a +143 underdog. The over/under for total runs scored is 7.5. (See the latest'lines for every game on our MLB odds page.)
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