San Francisco 49ers vs. Arizona Cardinals Prediction, Preview, and Odds – 11-21-2022

NFL Round Table Show

Arizona and San Francisco will play in Mexico City on Monday Night Football, pitting a 5-4 Niners squad against a 4-6 Cardinals unit. The 49ers are 3-2 over their past five and have won consecutive games. The Cardinals are 2-3 over the same span after defeating the Rams last week at home. Kickoff from Estadio Azteca will be at 8:15 pm EDT. San Francisco is an eight-point spread favorite, and the game total is 43.5 points.

The 49ers are hot, with consecutive wins over the LA teams and first place in the NFC West within their reach. San Francisco's offense is legit, with a few star playmakers that attract a lot of attention in Brandon Aiyuk (567 receiving yards and 4 TDs), Deebo Samuel (576 all-purpose yards and 3 TDs), George Kittle (340 receiving yards and 2 TDs), Elijah Mitchell (18 carries for 89 yards vs. LAC), and Christian McCaffrey (288 all-purpose yards and 3 TDs with SF). Aiyuk, Samuel, and Kittle have been reinvigorated by Mitchell's return from an MCL sprain and McCaffrey's arrival via trade, giving quarterback Jimmy Garoppolo a stacked deck.

Yet, last week versus the Chargers, the defense led the way. San Francisco kept Los Angeles off the scoreboard in the second half, the second straight game it has done so. Instead of collapsing, SF has rallied since surrendering 44 points to Kansas City in week 8, and the res ults are clear as day.

“We know that we're we're one of the best defenses in the league,” linebacker Fred Warner said. “We've shown that throughout the season. One bad game doesn't define you.”

This season, the Niners are ranked first in total yards allowed, second in rushing yards allowed, eighth in passing yards allowed, and fourth in points allowed per game. The defense has tallied 29 sacks, too, led by Nick Bosa (9 sacks and 11 tackles for loss). San Francisco's 26 takeaways rank as the 8th-most in the NFL, as well.

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