The San Francisco 49ers (5-4) and Arizona Cardinals (4-6) face off in the NFL’s final international game of the season. They play Monday night at Estadio Azteca in Mexico City with kickoff at 8:15 p.m. ET' (ESPN). Below, we analyze Tipico Sportsbook’s lines around the 49ers vs. Cardinals odds, and make our expert NFL picks and predictions.
The Cardinals beat the Rams 27-17 in Week 10 as 3.5-point underdogs. QB Colt McCoy, starting in place of an injured'Kyler Murray, threw a TD pass and RB James Conner'rushed for 2 TDs. The win snapped a 2-game losing streak.
The 49ers beat the Los Angeles Chargers 22-16 last week but failed to cover the 8.5-point spread as favorites. They have won 2 straight games and are undefeated in NFC West games.
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