Saints vs. 49ers Week 12 Prediction and Odds – Nov 27, 2022

The San Francisco 49ers square off with the New Orleans Saints in NFL Week 12 action at Levi's Stadium on Sunday, starting at 4:25PM ET.

Dimers' free betting picks for Saints vs. 49ers, as well as game predictions, betting odds and projected player stats, are featured below.

 

Who will win Saints vs. 49ers?

Based on high-tech computer power and data, Dimers.com has simulated Sunday's Saints-49ers NFL game 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, gives the 49ers a 79% chance of winning against the Saints in Week 12 of the NFL season.

More: Free Betting Guide for Saints vs. 49ers

Saints vs. 49ers Odds

  • Spread: 49ers -8.5 (-105), Saints +8.5 (-114)
  • Moneyline: 49ers -365, Saints +300
  • Total: Over/Under 42.5 (-105/-115)

  
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By Dimers