:format(webp)/cdn.vox-cdn.com/uploads/chorus_image/image/71604496/usa_today_17723124.0.jpg "Pick against the spread for Bellarmine-Louisville on November 9")
The Louisville Cardinals tip off the season by playing Bellarmine, who reside in the same city and would love to send a statement on the road on Wednesday.
Bellarmine Knights vs. Louisville Cardinals (-10.5, 135)
The Knights won the Atlantic Sun Tournament last season but could not go to the NCAA Tournament due to rules from teams transitioning from the non-Division I level.
They will look to put a new-look Louisville guard stable under duress with El Ellis being the only player in the backcourt with meaningful Division I experience, averaging 8.7 points per game last season.