Oddsmakers have released opening lines for NFL Week 4, and there are several outstanding matchups on the slate. Two Super Bowl favorites face off on Sunday Night Football when the Tampa Bay Buccaneers host the Kansas City Chiefs, and one night later the defending champion LA Rams visit the San Francisco 49ers on Monday Night Football.
In this article, you’ll find current Week 4 NFL odds from legal US sportsbooks, along with key storylines and betting insights for every matchup.
NFL Week 4 opening odds
Week 4 best odds and betting breakdown
- Spread: Dolphins , Bengals
- Moneyline: Dolphins , Bengals
- Total:
The Dolphins won a thriller against Buffalo in Week 3 to take sole possession atop the AFC East standings. Miami’s defense allowed another huge game through the air, allowing 400 yards to Josh Allen, but strung together some big stops in the red zone to secure a late win. The Dolphins face another high-powered passing offense in Week 4.
Bengals fans can take their finger off the panic button. Cincinnati finally found the win column, but it did come against the lowly Jets. After throwing four interceptions in the first two games, Joe Burrow kept that column clean in the 27-12 win over New York. He has a short week to prepare for Miami’s blitz-heavy attack.
- Spread: Vikings , Saints
- Moneyline: Vikings , Saints
- Total:
Things were looking bleak for the Vikings late against Detroit in Week 3, but timely turnovers and a late Kirk Cousins TD to KJ Osborn got the Vikings a much-needed win over the division rival Lions. Dalvin Cook left the game in the second half with a shoulder injury; his status will be worth watching this week, but Alexander Mattison is a serviceable replacement.