This season at BettingPros, we're asking some of our experts to give leans and top picks for every game on the NFL slate. Here are all of their leans, picks, best bets and predictions for Week 10.
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Week 10 Spread Leans for Each Game
| Home Team | Away Team | Home Spread | Fitzmaurice | Freedman | Santora | MacMillan | Wolbransky |
| TB | SEA | -2.5 | TB | TB | SEA | TB | SEA |
| BUF | MIN | -6.5 | BUF | MIN | MIN | MIN | BUF |
| TEN | DEN | -3 | TEN | DEN | DEN | DEN | TEN |
| MIA | CLE | -4 | MIA | MIA | CLE | CLE | CLE |
| PIT | NO | 2.5 | PIT | PIT | NO | PIT | NO |
| CHI | DET | -3 | DET | DET | DET | CHI | CHI |
| NYG | HOU | -6.5 | NYG | HOU | HOU | HOU | NYG |
| KC | JAX | -9.5 | KC | KC | JAX | KC | JAX |
| LV | IND | -6 | LV | LV | IND | LV | LV |
| GB | DAL | 5 | DAL | DAL | DAL | GB | DAL |
| LAR | ARI | -3 | ARI | ARI | ARI | ARI | ARI |
| SF | LAC | -7 | LAC | LAC | LAC | LAC | LAC |
| PHI | WAS | -10.5 | WAS | PHI | WAS | WAS | PHI |
LV -6 vs. IND
For the Colts, interim HC Jeff Saturday has never coached an NFL or college game or served on an NFL or college staff. The Ted Lasso vibes around Saturday and this organization are unreal. Interim OC Parks Frazier has never coordinated an offense or called plays at any level. And third string-turned-starting QB Sam Ehlinger has a sixth-round draft pedigree, just two starts and a 5.0 AY/A in the NFL. I expect the Colts to be extremely conservative on offense. That means they'll settle for field position and field goals. Translation: They will be incredibly suboptimal as they “get back to basics.” To that end, I anticipate that the Colts will heavily lean on the running game, especially since No. 1 RB Jonathan Taylor (ankle) returned to practice on Wednesday (albeit limitedly). But here's the problem: The Colts are terrible running the ball, the Raiders have no reason not to stack the box, and they're already average at worst against the run. If the Raiders can't shut down this tragicomedy of an offense and cover the spread, HC Josh McDaniels should be terminated immediately.
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