NFL training camps are underway, and Week 1 of the NFL regular season is right around the corner. The action kicks off on Thursday, Sept. 8 with a potential Super Bowl preview. The Buffalo Bills hit the road to take on the defending champion Los Angeles Rams for a highly-anticipated matchup of two of the league’s best.
Monday Night Football closes out the week with a homecoming of sorts for Russell Wilson as he leads the Denver Broncos to his old stomping grounds to take on the Seattle Seahawks. In between the two primetime games is a jam-packed Sunday of NFL action that features 14 games, including a possible revenge spot for Baker Mayfield as the Carolina Panthers welcome the Cleveland Browns to town.
Sportsbooks have released lines for all of the Week 1 matchups. Let’s take a look at what’s on tap and the latest numbers, followed by the key storylines to watch for each game.
NFL Week 1 odds: Spread, moneyline and totals
Odds for NFL Week 1 are available for betting. Six of the 16 games currently have spreads set at a field goal or less. The season opener is the lowest with a 1-point spread for Bills vs. Rams, while the largest has the Colts favored by 8.0 over the Texans. As for totals, the Chiefs vs. Cardinals is the biggest on the board at 53 points, while a pair of games share the low mark at 41.5. Below is a real-time look at the latest Week 1 lines from the top sportsbooks.
Week 1 NFL betting lines and schedule
| Date | Spread | Moneyline | Over/Under |
|---|---|---|---|
| Thursday, Sept. 8 | Bills (-1) @ Rams |
Bills -110 Rams -110 |
O/U 52.0 |
| Sunday, Sept. 11 | Eagles (-4) @ Lions |
Eagles -190 Lions +160 |
O/U 46.5 |
| Sunday, Sept. 11 | Ravens (-6) @ Jets |
Ravens -240 Jets +200 |
O/U 45.0 |
| Sunday, Sept. 11 | Jaguars @ Commanders (-3.5) |
Jaguars +155 Commanders -180 |
O/U 43.5 |
| Sunday, Sept. 11 | 49ers (-6.5) @ Bears |
49ers -275 Bears +230 |
O/U 42.0 |
| Sunday, Sept. 11 | Saints (-4.5) @ Falcons |
Saints -205 Falcons +175 |
O/U 41.5 |
| Sunday, Sept. 11 | Colts (-8) @ Texans |
Colts -380 Texans +310 |
O/U 44.0 |
| Sunday, Sept. 11 | Steelers @ Bengals (-6.5) |
Steelers +240 Bengals -285 |
O/U 44.5 |
| Sunday, Sept. 11 | Patriots @ Dolphins (-2.5) |
Patriots +115 Dolphins -135 |
O/U 44.0 |
| Sunday, Sept. 11 | Browns (-1) @ Panthers |
Browns -110 Panthers -110 |
O/U 41.5 |
| Sunday, Sept. 11 | Giants @ Titans (-6.5) |
Giants +235 Titans -280 |
O/U 43.5 |
| Sunday, Sept. 11 | Chiefs (-3) @ Cardinals |
Chiefs -155 Cardinals +135 |
O/U 53.0 |
| Sunday, Sept. 11 | Raiders @ Chargers (-3.5) |
Raiders +145 Chargers -170 |
O/U 52.0 |
| Sunday, Sept. 11 | Packers (-2) @ Vikings |
Packers -130 Vikings +110 |
O/U 49.0 |
| Sunday, Sept. 11 | Buccaneers (-2) @ Cowboys |
Buccaneers -130 Cowboys +110 |
O/U 52.0 |
| Monday, Sept. 12 | Broncos (-4.5) @ Seahawks |
Broncos -200 Seahawks +170 |
O/U 42.0 |
*NFL Week 1 betting odds via DraftKings Sportsbook
Last updated: July 25, 2022