Entering the 2024-25 NFL season, the 49ers are the biggest favorite to capture their respective division.'
San Francisco, who represented the NFC in Super Bowl 58, claimed their second straight division title in 2023 by two games over the Los Angeles Rams.'
Here's a look at the NFL betting lines for the NFC West division winner and my best bet.'
NFL Odds – NFC West Division Winner
- San Francisco 49ers: -225
- Los Angeles Rams: +425
- Seattle Seahawks: +650
- Arizona Cardinals: +1100
NFL Picks & Predictions – NFC West Division Winner
If the Rams and Seahawks proved less fortunate last season, I would consider a bet on them to eclipse San Francisco.'