New Orleans Saints vs San Francisco 49ers Prediction, 11/27/2022 NFL Picks, Best Bets & Odds Week 12
The New Orleans Saints (4-7) are en route to Levi's Stadium on Sunday where they will try to beat the San Francisco 49ers (5-4). New Orleans opens this contest as 8.5-point underdogs. The total has been set at 41.5. This matchup report includes betting lines and our NFL pick of the day for this game.

  
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