No college basketball fan will ever forget the 2005-06 George Mason Patriots.
After entering the NCAA as an 11-seed, the Patriots ran through No. 6 Michigan State, which made the Final Four the previous season, and No. 3 North Carolina, the defending national champions.
Following two more victories over No. 7 Wichita State and No. 1 UConn, George Mason made history by becoming the second double-digit seed to reach the Final Four and the first double-digit mid-major to accomplish the feat.
Since then, only four double-digit seeds have made their way past the Elite Eight and into the Final Four: No. 11 VCU in 2011, No. 10 Syracuse in 2016, No. 11 Loyola Chicago in 2018 and No. 11 UCLA in 2021.