The San Diego Padres host the Minnesota Twins to kick off an intriguing three-game interleague series on Friday night as part of a 15-game MLB schedule. The Seattle Mariners will be trying to snap a four-game losing skid to AL West rivals the Houston Astros (8:10 p.m. ET). Meanwhile, the Tampa Bay Rays host the Cleveland Guardians (7:10 p.m. ET) in a matchup of AL Wild-Card contenders. The Twins are in first place in the AL Central, two games up on Cleveland. The Padres are second in the NL West, 12 games behind the D odgers but second to the defending World Series champion Braves in the Wild-Card standings.'
First pitch for the Twins vs. Padres matchup at Petco Park is set for 9:40 p.m. ET. San Diego is the -130 favorite on the moneyline in the latest Padres vs. Twins odds from Caesars Sportsbook. The Twins are +115 underdogs, and the Over/Under for total runs is 7.5.'
The full 15-game Friday MLB schedule provides tons of opportunities for wagers, and you can cash in big if you combine your favorite picks in a parlay. (See up-to-date'lines for every game on our MLB odds page.)
Before you make any MLB picks or parlays, be sure to see the MLB predictions and betting advice from SportsLine's proven computer model.