Indianapolis Colts at Buffalo Bills odds, picks and predictions

The Indianapolis Colts face off against the Buffalo Bills Saturday in each team’s first preseason game. Kickoff from Highmark Stadium is set for 1 p.m. ET. Below, we analyze BetMGM Sportsbook’s'lines around the Colts vs. Bills'odds, and'make our expert NFL picks and predictions.

The Colts finished last season with a dismal 4-12-1 overall record and they chased offensive talent and selected QB'Anthony Richardson out of Flordia with the No. 4 overall pick in the 2023 draft. Indianapolis made other moves to increase their offensive firepower signing WR Isaiah McKenzie'and RB'Kenyan Drake.

There are still looming concerns around RB'Jonathan Taylor'heading into the 2023 campaign as the star running back remains on the PUP (physically unable to perform) list.

The Bills closed out the season with a 13-3 record and winning the AFC East, ultimately falling to the Cincinnati Bengals in the divisional round of the playoffs. Buffalo selected TE Dalton Kincaid'out of Utah with the 25th pick in the draft, adding another weapon for QB Josh Allen.

  
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