A pair of 2022 NFC playoff teams battle as the San Francisco 49ers host the New York Giants, and we have you covered with our best Giants-49ers predictions for Thursday Night Football based on the top NFL odds from our best sports betting apps.
The New York Giants were staring at a disastrous 0-2 start, but they tied a franchise record with the team's largest comeback (21 points) while facing the Arizona Cardinals on Sunday, matching a feat not accomplished since 1949.
Meanwhile, San Francisco won its ninth straight regular-season meeting with the Los Angeles Rams and has now taken 12 consecutive regular-season outings overall for the first time since 1989-90.
Here is our best Giants-49ers prediction for Thursday Night Football (odds via our best NFL betting sites; Pick confidence is based on a 1-to-5-star scale).
Giants vs. 49ers prediction: Thursday Night Football
The Giants had been outscored 60-0 through a game-and-a-half and were held scoreless across their first six quarters of a season for the first time since 1934. Thus, while their comeback from being 20-0 down at halftime and 28-7 in the third quarter against the Cardinals helped to cool off criticism for a week, significant problems persist.
New York will likely be without Saquon Barkley with this game being played on a short week, as ESPN's Adam Schefter reports he's dealing with an ankle issue. That's not good news for quarterback Daniel Jones, who played 34 games with Barkley entering 2023-24 and had produced a 44:17 touchdown-to-interception ratio while averaging 230 passing yards per game. Jones has posted a 16:17 TD:INT ratio while averaging 198 passing yards per game across 19 contests without Barkley. Furthermore, the Giants register ed a +40.1 offensive EPA, averaged 5.4 yards per play, and 4.7 yards per rush with Barkley healthy and active over the last five seasons entering 2023-24. Without Barkley, those numbers plummet to a -126.9 offensive EPA, 5.0 yards per play, and 4.2 yards per rush.
Jones made history during the second half against Arizona, as Boomer Esiason explained. However, it's unreasonable to think the team can put that much on his shoulders again with a one-dimensional offense and expect to compete against a team as explosive as the 49ers. Christian McCaffrey has scored a touchdown in 11 straight games (including playoffs), and while Brock Purdy's streak of six consecutive outings with two-plus passing touchdowns and a 95.0 or better passer rating was snapped in Week 2, he still posted an impressive 93.1 passer rating and played turnover-free football. Purdy is the eighth quarterback since 1950 to win his first seven regular-season starts.
It's therefore only a matter of how much San Francisco will win by on Thursday, and the 49ers are the fourth-most profitable ATS team over the last two seasons (26-15-1). We're comfortable laying less than double digits against a banged-up Giants team.
Not intended for use in MA
Affiliate Disclosure: Sportsbook Review may receive advertising commissions for visits to a sportsbook
Visit our Google News page and click “Follow” (?) for the latest odds, picks and news!
Giants vs. 49ers best odds
| DraftKings | FanDuel | BetMGM | Caesars | bet365 |
|---|---|---|---|---|
| -10 | -9.5 | OFF | -9.5 | -10.5 |
| -110 | -110 | OFF | -110 | -110 |
Seeing our best live betting sites on either side of the key betting number of -10 is interesting. 49ers backers get an easy choice of heading to FanDuel or Caesars, where they don't need to pursue alternate point spreads to get off of or move from under the key figure.
Purdy is 7-2-1 ATS across 10 career starts, but teams at home on Thursday Night Football are 24-38 ATS since 2019.
Giants vs. 49ers odds for Thursday Night Football
Giants vs. 49ers odds analysis
The lookahead line for this game was 49ers -6 in late August, but New York's issues through the first two weeks and Barkley's injury status made it balloon quickly. FanDuel and Caesars arrived at -10.5 late Monday morning before Giants backers scooped that number up quickly, driving the line down considerably. No shop has reached -11 or higher yet.
FanDuel is the only one of our best sportsbooks offering a total of 44.5, as every other book is at 45. DraftKings was the only shop to reach 45.5 on Sunday night, but it's since settled in with the majority of the market at 45 throughout Monday. There's good early two-way betting action on the total, with a slight percentage (54%) in favor of the Under.
Thursday Night Football game info
- When: Thursday, Sept. 21 at 8:15 p.m. ET
- Where: Levi's Stadium, Santa Clara, CA
- How to watch: Prime Video
- Weather: 77 degrees, 6% chance of precipitation, wind 11-mph southwesterly winds
Giants-49ers prediction made 9/18/23 at 11:33 a.m. ET
Kentucky sports betting will launch Sept. 28 so get pre-launch offers before it's too late! Don't miss out on Kentucky sportsbook promos or the best Kentucky sports betting apps!
21+ and present in KY. Gambling Problem? Call 1-800-GAMBLER
NFL betting odds pages
| Super Bowl Odds | NFL Defensive Rookie of the Year Odds | NFL Sacks Leader Odds |
| NFL MVP Odds | NFL Comeback Player of the Year Odds | NFL Best Record Odds |
| NFL Offensive Player of the Year Odds | NFL Most Regular Season Passing Yards Odds | NFL Worst Record Odds |
| NFL Defensive Player of the Year Odds | NFL Most Regular Season Rushing Yards Odds | NFL Win Totals Odds |
| NFL Coach of the Year Odds | NFL Most Regular Season Receiving Yards Odds | NFL Draft Odds |
| NFL Offensive Rookie of the Year Odds |
Check out our best NFL betting sites:
- Caesars Promo Code: SBRBONUSGET | Read our Caesars Review
- BetMGM Bonus Code: SBRBONUS | Read our BetMGM Review
- bet365 Bonus Code: SBRBONUS | Read our bet365 Review
- BetRivers Promo Code: SBRBONUS | Read our BetRivers Review
- FanDuel Promo Code | Read our FanDuel Review
- DraftKings Promo Code | Read our DraftKings Review
(21+. Gambling Problem? Call 1-800-GAMBLER)
* Bonuses not applicable in Ontario.
Related pages
- Best Sports Betting Sites | Best Sportsbook Promos (U.S. only)