Denver Broncos at Arizona Cardinals odds, picks and predictions

The Denver Broncos open their preseason slate on the road Friday against the Arizona Cardinals. Kickoff from State Farm Stadium is at 10 p.m. ET (NFL Network). Below, we analyze BetMGM Sportsbook’s lines around the Broncos vs. Cardinals odds, and'make our expert NFL picks and predictions.

Both the Broncos and Cardinals debut new coaching staffs after a bad 2022 season.

The Broncos will go with QB Russell Wilson under center after a disastrous first season with the club but now have Sean Payton taking over as head coach and new defensive coordinator Vance Joseph joins from the Cardinals after spending 4 years in Arizona. Denver could be missing starting OL Mike McGlinchey and S Justin Simmons, both of whom were injured this week.

The Cardinals also hired a new head coach in Jonathan Gannon, who joins from the Philadelphia Eagles. His coordinators, Drew Petzing and Nick Rallis, are first-time coordinators. QB Kyler Murray (knee) and TE Zach Ertz (knee) are on the PUP and haven’t resumed practicing after suffering knee injuries last season.

Broncos at Cardinals odds

  
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