Cubs-Cardinals prediction: Picks, odds on Saturday, June 24

For the first time in five years and just the second time ever, Major League Baseball will be played in London this weekend as the Chicago Cubs and St. Louis Cardinals renew their rivalry across the pond. First pitch of Saturday's series opener is set for 1:10 p.m. ET from historic London Stadium. Lefty Justin Steele (7-2, 2.71 ERA) will get the ball for Chicago, while St. Louis turns to veteran Adam Wainwright (3-1, 5.56).

Chicago enters as the -140 favorite on the moneyline at DraftKings Sportsbook, with the Cardinals at +120. The run total is set at a whopping 13.5. (Here's your reminder that the New York Yankees and Boston Red Sox combined for 10 homers and 50 runs across their two games at the rather tiny London Stadium back in 2019.)