Commanders vs. 49ers prediction, odds, spread, line, start time: 2023 NFL picks, Week 17 best bets from proven simulation model

The Washington Commanders and the San Francisco 49ers are set to square off in an NFC battle at 1:00 p.m. ET on December 31st at FedEx Field. Washington is 4-11 overall and 1-5 at home, while San Francisco is 11-4 overall and 6-2 on the road. The 49ers are coming off a 33-19 loss to the Baltimore Ravens, but still hold the No. 1 seed in the NFC Playoffs. The Commanders are looking to snap a six-game losing streak after falling 30-28 to the New York Jets in Week 1 6.
  
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