- Without Kyler Murray, the Cardinals are 10-point underdogs on Monday Night Football.
- This matchup is a Cardinals home game that is taking place in Mexico City.
- Chris Raybon previews the game and makes his betting pick below.
Cardinals vs 49ers Odds
Monday, Nov. 21 8:15 p.m. ET ESPN
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
| +10 -110 | 43.5 -105o / -115u | +360 |
| 49ers Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
| -10 -110 | 43.5 -105o / -115u | -460 |
Odds via'FanDuel.'Get up-to-the-minute'NFL odds here.
This NFC West tilt will be the fifth game the NFL has played at Estadio Azteca in Mexico City. Favorites are 4-0 against the spread in Mexico City and overs are 2-2.
The Cardinals are expected to start Colt McCoy at quarterback for the second straight week in place of Kyler Murray, who is nursing a hamstring injury. McCoy is 3-1 ATS as a starter for Arizona, including a perfect 3-0 mark as an underdog.
Toggle the dropdowns below to hide or show how the Cardinals and 49ers'match up statistically:
Cardinals vs 49ers DVOA Breakdown
| Offense | Defense | Edge | |
| Overall DVOA | 14 | 21 | |
| Pass DVOA | 7 | 19 | |
| Rush DVOA | 23 | 16 |
| Offense | Defense | Edge | |
| Overall DVOA | 28 | 8 | |
| Pass DVOA | 29 | 10 | |
| Rush DVOA | 27 | 3 |