Buffalo Bills vs. Detroit Lions Prediction, Preview, and Odds – 11-24-2022

The Detroit Lions (4-6) will host the Buffalo Bills (7-3) on Thanksgiving Day. This will be the first head-to-head meeting between these teams since 2018.

The Buffalo Bills are favored to win the Super Bowl this season with +450 odds according to Draft Kings. The Bills jumped out to a 6-1 start this season before suffering back-to-back three-point upset losses to the Jets and Vikings. Buffalo bounced back on Sunday, winning a “home game” in Detroit 31-23 over the Browns, in a contest that was moved due to extreme snowstorms in the Buffalo area. Winning the battle in the running game is not easy against Cleveland, but the Bills rushed 33 times for 171 yards while holding the Browns to just 80 yards on 26 carries, with Nick Chubb being shut down for 19 yards on 14 attempts. Devin Singleton ran the ball 18 times for 86 yards for the Bills, both season highs.

The Bills have also been stingy on defense, ranking 13th allowing 327.4 yards per game, but fifth-best, holding opponents to just 17.4 ppg. Offensively, Buffalo is in the top 10 in scoring, total offense, passing and rushing yards. Quarterback Josh Allen is second in the NFL with 2,930 passing yards per game and third with 21 touchdowns and a 73.3 QBR. Allen has also thrown 10 picks. Stefon Diggs is Allen's top target ranking second in the NFL with 76 catches and third with 1,033 yards and eight touchdowns.

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