Week 2 of March Madness is upon us. The madness? That’s mostly the upsets that happen in just about every bracket region every year. After looking at Tipico Sportsbook’s NCAA Tournament odds and lines, here is Friday’s best Sweet 16 upset pick among our expert college basketball picks and predictions.
Friday’s action includes games in the Midwest Region semifinals i Kansas City and the South Region semis i Louisville. The combatants come from chalky and not-so-chalky parts of the brackets. The best upset opportunity lies with a tweener seed in the South.
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Friday’s best Sweet 16 upset pick
Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Thursday at 11:38 p.m. ET