2024 NCAA Tournament: Iowa State vs. Illinois prediction, odds, line, spread picks for Sweet 16 game from proven model

The second-seeded Iowa State Cyclones attempt to slow down Illinois' offense when they face the No. 3 seed Fighting Illini in the East Region semifinals of the 2024 NCAA Tournament on Thursday. Iowa State (29-7) has reached the Sweet 16 for the second time in three years after posting victories against South Dakota State and Washington State. The Cyclones now take on high-scoring Illinois (28-8), which defeated Morehead State 85-69 and Duquesne 89-63 en route to its first Sweet 16 appearance since 2005.
  
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