2022 San Francisco 49ers Preview – Super Bowl Odds & Best Bets

It will be a new era in San Francisco in 2022 as Trey Lance will take over as quarterback. Jimmy G will be replaced, and the veteran could be on the move before the season begins. The 49ers have a lot of potential, but are there holes in their offense that could lead to their downfall? There certainly will be if San Francisco can’t reach a deal with Deebo Samuel, which still remains a top priority for the 49ers. They had a solid season in 2021, so let’s see what they can do in 2022.

San Francisco 49ers breakdown

2021 record: 10-7

2022 ATS record: 9-8

2021 O/U record: 8-9

  
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