NFL Week 10 opening lines, spreads and odds

Week 9 was an exciting week that featured several nail biters and a few blowouts (watch out for the Ravens!). Some of the best performances included CJ Stroud throwing for 470 yards, Josh Dobbs leading the Vikings to a win less than a week after arriving in Minnesota and Patrick Mahomes and the Chiefs getting a victory in Germany.

Sportsbooks announced games lines for the next week on Sunday night, so here are the opening lines for Week 10.

NFL Week 10 opening lines and odds

Carolina Panthers +3 (-115) vs Chicago Bears -3 (-105) – Thursday Night Football
Indianapolis Colts -1.5 (-110) vs New England Patriots +1.5 (-110)
San Francisco 49ers -2.5 (-105) vs Jacksonville Jaguars +2.5 (-115)
Houston Texans +7.5 (-105) vs Cincinnati Bengals -7.5 (-115)
Cleveland Browns +4.5 (-110) vs Baltimore Ravens -4.5 (-110)
New Orleans Saints -2 (-110) vs Minnesota Vikings +2 (-110)
Tennessee Titans +1.5 (-118) vs Tampa Bay Buccaneers -1.5 (-102)
Green Bay Packers +2.5 (-104) vs Pittsburgh Steelers -2.5 (-116)
Detroit Lions -1.5 (-102) vs Los Angeles Chargers +1.5 (-120)
Atlanta Falcons -1.5 (-120) vs Arizona Cardinals +1.5 (-102)
New York Giants +15.5 (-110) vs Dallas Cowboys -15.5 (-110)
Washington Commanders +5.5 (-110) vs Seattle Seahawks -5.5 (-110)
New York Jets -1.5 (-110) vs Las Vegas Raiders +1.5 (-110) – Sunday Night Football
Denver Broncos +8.5 (-110) vs Buffalo Bills -8.5 (-110) – Monday Night Football

Best early bet for NFL Week 10: Baltimore Ravens -4.5 (-110)

  
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