The Los Angeles Chargers survived a thriller in Atlanta last week, while the San Francisco 49ers continued their domination of the L.A. Rams before their bye week. Read on for our top Chargers vs. 49ers Week 10 predictions.
Neither the Chargers nor the 49ers have been as dominant as many expected them to be preseason. The Chargers are 5-3 overall, and have won four of their last five games. Despite their 3-1 road record, they've struggled to pick up victories, winning by a combined five points in their last two road mat chups.
San Francisco lost two of three, though the 49ers did overpower the Rams their last time out. In that game, San Francisco running back Christian McCaffrey looked like all he was advertised to be, rushing for 94 yards and a touchdown. He also pulled in eight passes for 55 yards and one TD, and even threw for a score.
Here are our Chargers vs. 49ers NFL Week 10 picks (odds via DraftKings Sportsbook and PointsBet; pick confidence based on a 1-to-5-star scale).