Minnesota Twins vs. Chicago White Sox Prediction, Preview, and Odds – 5-3-2023

The Minnesota Twins and Chicago White Sox will square off on Wednesday at Guaranteed Rate Field. First pitch from the Windy City is at 7:10 p.m. ET.

Minnesota (17-12 SU and 17-12 RL) has won back-to-back series. The Twins are starting right-hander Louie Varland in game two of the three-game set. The 25-year-old is 0-0 with a 4.50 ERA in one start this season.

Chicago (8-21 SU and 11-18 RL) is hoping to build off of its recent victory over Tampa Bay. The White Sox will give the game ball to starter Dylan Cease on Wednesday. The 27-year-old is 2-1 with a 4.15 ERA in six appearances this year.

The White Sox are -130 moneyline favorites and the game total is eight.

The Twins are searching for another series victory over an AL Central rival this week in Chicago. Can the Southsiders put an end to Minnesota's hot start?

Minnesota scores 4.62 runs per contest (14th) and hits .237 (21st) with a .723 OPS (16th). The Twinkies have hit 38 homers (6th) and stolen four bases (30th) in 2023. DH Byron Buxton leads the Twins in batting average (.258) and home runs (7), while LF Trevor Larnach paces the team in OBP (.354) and RBI (18). The pitching staff has compiled a 3.48 ERA (5th) and a 1.13 WHIP (2nd) with the sixth-most quality starts, 12, in MLB.

Varland will take the mound tomorrow for the visiting Twins, sliding into the spot vacated by Tyler Mahle, who was just shut down with an elbow injury. He sported a 4.20 ERA and 25:4 K-BB ratio in 15 innings with Triple-A St. Paul. In his lone big league start this year against the New York Yankees, Varland surrendered three runs on six hits with eight strikeouts in six innings.

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