This season at BettingPros, we’re asking some of our experts to give leans and top picks for every game on the NFL slate. Here are all of their leans, picks, and predictions for Week 1.
Prop Bet Analyzer: View top rated props and historical prop performance by player >>
| Home Team | Away Team | Home Spread | Fitzmaurice | Freedman | LaMarca | Greer | Wolbransky | Santora | MacMillan | Home Leans | Away Leans |
| DET | PHI | 4 | DET | DET | DET | DET | DET | PHI | PHI | 5 | 2 |
| CHI | SF | 7 | CHI | CHI | SF | CHI | CHI | CHI | CHI | 6 | 1 |
| CIN | PIT | -6.5 | PIT | PIT | PIT | PIT | PIT | CIN | PIT | 1 | 6 |
| MIA | NE | -3.5 | NE | NE | MIA | NE | NE | NE | NE | 1 | 6 |
| CAR | CLE | -1.5 | CLE | CLE | CLE | CAR | CAR | CLE | CAR | 3 | 4 |
| HOU | IND | 7 | HOU | HOU | HOU | HOU | HOU | IND | HOU | 6 | 1 |
| ATL | NO | 5.5 | ATL | ATL | NO | ATL | ATL | ATL | ATL | 6 | 1 |
| NYJ | BAL | 7 | BAL | NYJ | NYJ | NYJ | BAL | NYJ | BAL | 4 | 3 |
| WAS | JAX | -2.5 | JAX | JAX | JAX | JAX | JAX | WAS | WAS | 2 | 5 |
| MIN | GB | 1.5 | GB | GB | GB | MIN | GB | GB | MIN | 2 | 5 |
| TEN | NYG | -5.5 | NYG | NYG | NYG | TEN | NYG | TEN | NYG | 2 | 5 |
| LAC | LV | -3.5 | LAC | LAC | LV | LAC | LAC | LAC | LAC | 6 | 1 |
| ARI | KC | 6 | ARI | ARI | KC | ARI | KC | ARI | ARI | 5 | 2 |
| DAL | TB | 2.5 | DAL | DAL | DAL | DAL | TB | DAL | DAL | 6 | 1 |
| SEA | DEN | 6.5 | SEA | SEA | SEA | SEA | DEN | SEA | SEA | 6 | 1 |