In NFL spread betting, a +4.5 spread means that a team (the underdog) must lose by fewer than five points or win the game to cover the spread.'
For example, if Kyler Murray and the Arizona Cardinals lost a regular-season game to Dak Prescott and the Dallas Cowboys, 35-32, bettors who took the Cardinals odds of +4.5 would win.
However, if the Cowboys won 35-27, anyone who bet Eagles +4.5 would lose against the spread.
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