Week 1 Thursday Night Football NFL Odds, Picks & Predictions: Bills vs. Rams (2022)
Week 1 Thursday Night Football NFL Odds, Picks & Predictions: Bills vs. Rams (2022)

It’s the Tuesday after Labor Day, which officially means the NFL is back as we are now just hours away from the start of the season. Kicking us off this year are two teams amongst the favorites to make the Super Bowl, as the Buffalo Bills travel west to take on the reigning-champion Los Angeles Rams.

With expectations sky-high for both sides, let’s take a closer look at how this one might play out at SoFi Stadium.

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  • Opening Line: Rams +1, O/U 52
  • Current Line: Rams +2.5, O/U 52.5
  • Last meeting: September 27, 2020, Rams 32, Bills 35

  
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