The Washington Commanders (7-6-1) are on the road in Week 16 to take on the NFC West champion San Francisco 49ers (10-4). They play Saturday afternoon at 4:05 p.m. ET at Levis Stadium in Santa Clara (CBS). Below, we analyze Tipico Sportsbook’s'lines around the Commanders vs. 49ers odds, and make our expert NFL picks and predictions.
The Commanders lost to the New York Giants 20-12 last Sunday night at home as 4.5-point favorites. Their last 2 games were against the Giants. They won 3 in a row before that and currently are the No. 7 seed in the NFC.
The 49ers clinched the NFC West title with a 21-13 win over the Seattle Seahawks in Week 15 as 3-point favorites. They have won 7 games in a row.
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