Vanderbilt vs Missouri Prediction, Odds & Best Prop Bets – NCAAF, Week 4
Vanderbilt vs Missouri Prediction, Odds & Best Prop Bets – NCAAF, Week 4

The Vanderbilt Commodores (2-1) visit Memorial Stadium/Faurot Field to take on the Missouri Tigers (3-0) on Sep. 21 in Columbia, MO. Kickoff is scheduled for 4:15pm EDT.

Missouri is a betting favorite in Week 4, with the spread sitting at -20.5 (-115).

The Vanderbilt vs. Missouri Over/Under is 53.5 total points.

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Vanderbilt vs Missouri Prediction:

The winning team model predicts Missouri will win this game with 93.4% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both Vanderbilt and Missouri, key player performances this season and recent team trends.

Vanderbilt vs Missouri Spread Prediction:

Based on recent against-the-spread trends, the model predicts Missouri will cover the spread with 62.8% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


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  • Vanderbilt has hit the Game Total Over in 8 of their last 11 games (+4.70 Units / 39% ROI)
  • Vanderbilt has hit the 1H Game Total Under in 3 of their last 5 away games (+0.80 Units / 14% ROI)
  • Vanderbilt has hit the 1Q Game Total Under in 3 of their last 5 away games (+0.70 Units / 12% ROI)

  • Missouri has hit the 1H Moneyline in 9 of their last 11 games (+8.60 Units / 34% ROI)
  • Missouri has hit the Moneyline in 9 of their last 11 games (+7.75 Units / 26% ROI)
  • Missouri have covered the Spread in 9 of their last 12 games (+5.75 Units / 44% ROI)
  • Missouri have covered the 1H Spread in 9 of their last 12 games (+5.70 Units / 43% ROI)
  • Missouri has hit the 1H Game Total Under in 8 of their last 12 games (+3.85 Units / 29% ROI)

We’ve highlighted some favorite college football player prop bets for Vanderbilt players, looking at profitable historical betting trends:

Best Vanderbilt Player Prop Bets Today

  • Diego Pavia has hit the TD Passes Over in his last game (+1.00 Units / 45% ROI)

Top NCAAF player prop bets for Missouri players, looking at profitable historical betting trends:

Best Missouri Player Prop Best Bets Today

  • Brady Cook has hit the TD Passes Under in 6 of his last 7 games (+5.25 Units / 52% ROI)
  • Luther Burden III has hit the Receiving Yards Under in 6 of his last 7 games (+4.80 Units / 57% ROI)
  • Mookie Cooper has hit the Receiving Yards Under in his last 4 games (+4.00 Units / 83% ROI)
  • Brady Cook has hit the Passing Yards Over in 4 of his last 5 games at home (+2.80 Units / 47% ROI)
  • Theo Wease Jr. has hit the Receiving Yards Over in 6 of his last 9 games (+2.40 Units / 22% ROI)

Vanderbilt Against the Spread (ATS) Record

Vanderbilt is 2-1 against the spread this college football season (+0.9 Units / 27.27% ROI).

  • Vanderbilt is 1-1 when betting on the Moneyline for +0.55 Units / 12.36% ROI
  • Vanderbilt is 3-0 when betting the Over for +3 Units / 90.91% ROI
  • Vanderbilt is 0-3 when betting the Under for -3.3 Units / -100% ROI

Missouri Against the Spread (ATS) Record

Missouri is 1-1 against the spread this college football season (-0.05 Units / -2.33% ROI).

  • Missouri is 1-0 when betting on the Moneyline for +1 Units / 16.53% ROI
  • Missouri is 0-2 when betting the Over for -2.2 Units / -100% ROI
  • Missouri is 2-0 when betting the Under for +2 Units / 90.91% ROI

Vanderbilt is 1-9 (.077) when averaging less than 5 yards per rush since the 2023 season– T-4th-worst among Power Conference Teams; Average: .365

Vanderbilt is 1-10 (.091) when allowing 100 or more rushing yards since the 2023 season– T-10th-worst in FBS; Average: .391

Vanderbilt is 1-9 (.100) when having a turnover margin within one of the opposing team since the 2023 season– T-6th-worst in FBS; Average: .497

Vanderbilt is 1-8 (.111) when allowing 10 or more rushes of four or more yards since the 2023 season– T-6th-worst among Power Conference Teams; Average: .453

Missouri is 6-1 (.667) when committing less than 60 yards in penalties since the 2023 season– T-17th-best in FBS; Average: .441

Missouri is undefeated (9-0) when not throwing an interception since the 2023 season– T-6th-best in FBS; Average: .589

Missouri is 11-1 (.786) when rushing more than 30 times since the 2023 season– 16th-best in FBS; Average: .517

Missouri is 9-1 (.900) when allowing less than 50% of third down conversion opportunities since the 2023 season– 5th-best among Power Conference Teams; Average: .559

Missouri’s offense has thrown for 20 or more yards on just 6.2% of 113 attempts this season — T-15th-worst among FBS offenses. Vanderbilt’s defense allowed 20+ yards on 11.0% of attempts this season — 4th-best among SEC defenses.

Missouri’s QBs has thrown for 4,175 passing yards in 16 games (260.9 YPG) since the 2023 season — 33rd-best among FBS teams. Vanderbilt’s defense has allowed 265.1 passing yards per game since the 2023 season — 9th-worst among FBS defenses.

  
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