USC vs Michigan Prediction, Odds & Best Prop Bets – NCAAF, Week 4
USC vs Michigan Prediction, Odds & Best Prop Bets – NCAAF, Week 4

The USC Trojans (2-0) visit Michigan Stadium to take on the Michigan Wolverines (2-1) on Sep. 21 in Ann Arbor, MI. Kickoff is scheduled for 3:30pm EDT.

USC is a betting favorite in Week 4, with the spread sitting at -6 (-105).

The USC vs. Michigan Over/Under is 46.5 total points.

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USC vs Michigan Prediction:

The winning team model predicts USC will win this game with 65.2% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both USC and Michigan, key player performances this season and recent team trends.

USC vs Michigan Spread Prediction:

Based on recent against-the-spread trends, the model predicts Michigan will cover the spread with 70.4% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


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  • USC has hit the Game Total Over in 8 of their last 12 games (+3.60 Units / 27% ROI)
  • USC has hit the 1H Game Total Under in 4 of their last 6 away games (+1.95 Units / 30% ROI)
  • USC has hit the Moneyline in 3 of their last 5 away games (+1.55 Units / 8% ROI)
  • USC has hit the 1Q Moneyline in 3 of their last 5 away games (+1.00 Units / 6% ROI)
  • USC has hit the 1Q Game Total Over in 6 of their last 12 games (+0.20 Units / 1% ROI)

  • Michigan has hit the 1H Moneyline in 13 of their last 14 games (+12.00 Units / 11% ROI)
  • Michigan has hit the Moneyline in 13 of their last 14 games (+12.00 Units / 2% ROI)
  • Michigan have covered the 1Q Spread in 10 of their last 15 games (+4.55 Units / 26% ROI)
  • Michigan has hit the 1Q Game Total Over in 9 of their last 15 games (+3.60 Units / 21% ROI)
  • Michigan have covered the Spread in 9 of their last 15 games (+3.55 Units / 22% ROI)

We’ve highlighted some favorite college football player prop bets for USC players, looking at profitable historical betting trends:

Best USC Player Prop Bets Today

  • Zachariah Branch has hit the Receiving Yards Under in his last game (+1.00 Units / 87% ROI)
  • Lake McRee has hit the Receiving Yards Under in his last game (+1.00 Units / 83% ROI)
  • Miller Moss has hit the Passing Yards Over in his last game (+1.00 Units / 77% ROI)
  • Miller Moss has hit the TD Passes Over in his last game (+1.00 Units / 74% ROI)

Top NCAAF player prop bets for Michigan players, looking at profitable historical betting trends:

Best Michigan Player Prop Best Bets Today

  • Donovan Edwards has hit the Receiving Yards Under in his last 4 games (+4.00 Units / 82% ROI)
  • Donovan Edwards has hit the Rushing Yards Under in 6 of his last 8 games (+3.45 Units / 35% ROI)
  • Colston Loveland has hit the Receiving Yards Over in 4 of his last 5 games at home (+2.75 Units / 45% ROI)
  • Colston Loveland has hit the Receptions Under in his last game (+1.00 Units / 56% ROI)

USC Against the Spread (ATS) Record

USC is 2-0 against the spread this college football season (+2 Units / 88.89% ROI).

  • USC is 1-0 when betting on the Moneyline for +1.55 Units / 155% ROI
  • USC is 0-2 when betting the Over for -2.2 Units / -100% ROI
  • USC is 2-0 when betting the Under for +2 Units / 90.91% ROI

Michigan Against the Spread (ATS) Record

Michigan is 0-3 against the spread this college football season (-3.25 Units / -100% ROI).

  • Michigan is 2-1 when betting on the Moneyline for +1 Units / 3.29% ROI
  • Michigan is 1-2 when betting the Over for -1.2 Units / -36.36% ROI
  • Michigan is 2-1 when betting the Under for +0.9 Units / 27.27% ROI

USC is undefeated (5-0) when not losing a fumble since the 2023 season– T-best in FBS; Average: .498

USC is undefeated (8-0) when allowing less than 3 sacks since the 2023 season– best in FBS; Average: .524

USC is 9-4 (.643) when passing for more than 200 yards since the 2023 season– T-28th-best in FBS; Average: .480

USC is 15-1 (.938) when allowing less than 3 sacks since the 2022 season– 2nd-best in FBS; Average: .538

Michigan is undefeated (13-0) when averaging more than 5 yards on first down plays since the 2023 season– best in FBS; Average: .495

Michigan is undefeated (12-0) when making 7 or more explosive plays since the 2023 season– best in FBS; Average: .526

Michigan is 28-1 (.966) when rushing at least 4 yards in a play 10 or more times since the 2022 season– best in FBS; Average: .495

Michigan is 25-1 (.962) when committing less than 60 yards in penalties since the 2022 season– best in FBS; Average: .446

Michigan has gained 459 yards on 51 receptions (just 9.0 YPR) this season — 5th-worst among FBS skill players. USC’s defense has allowed just 8.7 Yards Per Reception this season — 5th-best among Big Ten defenses.

Michigan’s TEs has gained 246 yards on 24 receptions (just 10.2 YPR) this season — 5th-worst among Big Ten TEs. USC’s defense has allowed just 8.7 Yards Per Reception this season — T-16th-best among FBS defenses.

  
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