:format(webp)/cdn.vox-cdn.com/uploads/chorus_image/image/71354312/1422666703.0.jpg "Titans vs. Bills odds: Opening odds, point spread, total, predictions for Week 2 matchup")
The NFL is wrapping up its Week 1 Sunday slate and and remain. In the meantime, we've got some early odds to get you ready for Week 2. The Tennessee Titans and Buffalo Bills will face off this coming week, with kickoff set for 7:15 p.m. ET on Monday, Sept. 19.
Derrick Henry is officially back after missing most of the 2021 season, though the Titans were shocked in a 21-20 loss today to the New York Giants. Ryan Tannehill went 20-for-33 for 266 yards and two touchdowns, with Henry taking the majority of carries for 82 yards in the loss.
The Buffalo Bills made quick work of the reigning Super Bowl champions in this week's Thursday night kickoff, with Josh Allen racking up 297 passing yards and three touchdowns in a decisive 31-10 victory helped on by a seven (yep, sacks added by the Buffalo defense.
DraftKings Sportsbook posted opening odds for this matchup earlier this week. Here's a look at what the odds opened at and where they re-opened at for the Titans vs. Bills Week 2 matchup.
Titans vs. Bills
Point spread: Bills -9.5
Point total: 50
Moneyline: Bills -380, Titans +310
Point spread: Bills -8.5
Point total: 51
Moneyline: Bills -360, Titans +295
Opening point spread: Bills -7
Opening moneyline: Bills -365, Titans +280
Early pick: Bills -9.5
Allen and the Bills looked unstoppable against a team coming off a Super Bowl win. A team coming off a Giants loss – Derrick Henry or no Derrick Henry – should be quick work for them, especially if the defensive line can keep the same pressure up on Monday against Tannehill that they brought last Thursday.