Before you bet a prop, you should handicap the game. Looking at individual matchups like wide receiver versus defensive back and running back versus linebacker is fine, but the game state is really important.
Will a team need to play with more urgency and throw more passes in the second half? Will it be looking to slow down the pace and run out the clock?
Another thing you may want to look at is the trend line for snap counts. How often a player is expected to be on the field may be the deciding factor in how you play a prop, or if you play it all.
Don’t make the handicap overly simple and get tunnel vision. Think about all of the factors in play.