Here are my projected lines and totals, as well as my top bets for Week 1 of the 2022 college football season.
| Away | Home | ATL | Spread | Difference | ATT | Total | Difference | Day | CST |
| Central Michigan | Oklahoma St. | -16.2 | -22 | 5.8 | 49 | 58.5 | -9.5 | Thursday | 6:00 |
| West Virginia | Pittsburgh | -18.8 | -7.5 | -11.3 | 60.5 | 51.5 | 9 | Thursday | 6:00 |
| Ball St. | Tennessee | -32.0 | -35 | 3.0 | 62.5 | 67.5 | -5 | Thursday | 6:00 |
| Penn St. | Purdue | 3.4 | 3.5 | -0.1 | 45 | 53.5 | -8.5 | Thursday | 7:00 |
| Louisiana Tech | Missouri | -12.4 | -20.5 | 8.1 | 73.5 | 61.5 | 12 | Thursday | 7:00 |
| New Mexico St. | Minnesota | -36.4 | -36.5 | 0.1 | 60.5 | 53 | 7.5 | Thursday | 8:00 |
| Western Michigan | Michigan St. | -29.3 | -23.5 | -5.8 | 61 | 54.5 | 6.5 | Friday | 6:00 |
| Virginia Tech | Old Dominion | 10.5 | 7 | 3.5 | 45 | 48.5 | -3.5 | Friday | 6:00 |
| Temple | Duke | -5.8 | -7 | 1.2 | 60 | 51.5 | 8.5 | Friday | 6:30 |
| Illinois | Indiana | 2.1 | -3 | 5.1 | 42 | 46 | -4 | Friday | 7:00 |
| TCU | Colorado | 14.2 | 13.5 | 0.7 | 56.5 | 55.5 | 1 | Friday | 9:00 |
| Buffalo | Maryland | -17.3 | -24 | 6.7 | 66 | 65 | 1 | Saturday | 11:00 |
| Colorado St. | Michigan | -31.3 | -30.5 | -0.8 | 57 | 61.5 | -4.5 | Saturday | 11:00 |
| Rutgers | Boston College | -5.7 | -7 | 1.3 | 44.5 | 48 | -3.5 | Saturday | 11:00 |
| North Carolina | Appalachian St. | 2.9 | 0 | 2.9 | 67.5 | 56 | 11.5 | Saturday | 11:00 |
| North Carolina St. | East Carolina | 11.7 | 11.5 | 0.2 | 58 | 51.5 | 6.5 | Saturday | 11:00 |
| Bowling Green | UCLA | -23.7 | -23 | -0.7 | 62 | 57.5 | 4.5 | Saturday | 1:30 |
| Cincinnati | Arkansas | -2.0 | -6.5 | 4.5 | 58 | 52 | 6 | Saturday | 2:30 |
| Oregon | Georgia | -11.1 | -17 | 5.9 | 57 | 53 | 4 | Saturday | 2:30 |
| Arizona | San Diego St. | -1.4 | -6.5 | 5.1 | 44 | 47 | -3 | Saturday | 2:30 |
| Tulsa | Wyoming | 2.1 | 6.5 | -4.4 | 44 | 44 | 0 | Saturday | 2:30 |
| UTEP | Oklahoma | -30.1 | -31 | 0.9 | 64 | 56.5 | 7.5 | Saturday | 2:30 |
| Houston | UTSA | 5.9 | 4.5 | 1.4 | 65 | 62 | 3 | Saturday | 2:30 |
| Troy | Ole Miss | -16.3 | -21 | 4.7 | 58 | 57.5 | 0.5 | Saturday | 3:00 |
| Brigham Young | South Florida | 13.5 | 12 | 1.5 | 62 | 58.5 | 3.5 | Saturday | 3:00 |
| Texas St. | Nevada | -1.4 | -1 | -0.4 | 66 | 52 | 14 | Saturday | 4:30 |
| Florida Atlantic | Ohio | 4.0 | 3.5 | 0.5 | 48.5 | 49.5 | -1 | Saturday | 5:00 |
| Middle Tennessee | James Madison | -1.5 | -6 | 4.5 | 56 | 58 | -2 | Saturday | 5:00 |
| Rice | USC | -27.6 | -32.5 | 4.9 | 60.5 | 61.5 | -1 | Saturday | 5:00 |
| Utah | Florida | 2.9 | 3 | -0.1 | 60 | 50.5 | 9.5 | Saturday | 6:00 |
| Miami (OH) | Kentucky | -15.5 | -16.5 | 1.0 | 54 | 54 | 0 | Saturday | 6:00 |
| Army | Coastal Carolina | -3.6 | -2 | -1.6 | 60.5 | 53.5 | 7 | Saturday | 6:00 |
| Liberty | Southern Miss | 1.7 | 3.5 | -1.8 | 47 | 49.5 | -2.5 | Saturday | 6:00 |
| Massachusetts | Tulane | -26.4 | -28.5 | 2.1 | 63.5 | 58.5 | 5 | Saturday | 6:00 |
| Utah St. | Alabama | -44.6 | -41.5 | -3.1 | 71 | 62 | 9 | Saturday | 6:30 |
| Memphis | Mississippi St. | -16.9 | -16 | -0.9 | 60.5 | 56.5 | 4 | Saturday | 6:30 |
| Georgia St. | South Carolina | -8.1 | -12.5 | 4.4 | 46 | 56.5 | -10.5 | Saturday | 6:30 |
| Notre Dame | Ohio St. | -19.7 | -17 | -2.7 | 74 | 59 | 15 | Saturday | 6:30 |
| SMU | North Texas | 9.0 | 11 | -2.0 | 68 | 68.5 | -0.5 | Saturday | 6:30 |
| Louisiana-Monroe | Texas | -39.1 | -37.5 | -1.6 | 69.5 | 64.5 | 5 | Saturday | 7:00 |
| Louisville | Syracuse | 5.6 | 4.5 | 1.1 | 58.5 | 57 | 1.5 | Saturday | 7:00 |
| Boise St. | Oregon St. | -2.6 | -2.5 | -0.1 | 56.5 | 56.5 | 0 | Saturday | 9:30 |
| Kent St. | Washington | -24.5 | -23 | -1.5 | 56.5 | 59.5 | -3 | Saturday | 9:30 |
| Western Kentucky | Hawai’i | 12.0 | 16 | -4.0 | 80.5 | 67.5 | 13 | Saturday | 10:59 |
| Florida St. | LSU | -0.6 | -3.5 | 2.9 | 55.5 | 51.5 | 4 | Sunday | 6:30 |
| Clemson | Georgia Tech | 23.9 | 21 | 2.9 | 47.0 | 50.5 | -3.5 | Monday | 7:00 |