With quarterback Ryan Tannehill out for Tennessee, the Titans will lean on running back Derrick Henry to outmuscle the Houston Texans. Can King Henry lead Tennessee to another win over Houston? Read on for our top Texans-Titans NFL pick.
The Titans (1-12-1) are a virtual lock for the NFL's worst record and the No. 1 draft pick that comes with it, but they've been playing inspired football the last couple of weeks against playoff-bound teams.
Tennessee (7-7) is suddenly locked into a battle for the AFC South as it looks to stave off the hard-charging Jacksonville Jaguars.
Here is our best Texans-Titans Week 16 NFL pick (odds via DraftKings Sportsbook and Caesars Sportsbook; pick confidence based on a 1-to-5-star scale).