College football fans and bettors will get a different look at both the Tennessee Volunteers and Clemson Tigers when they meet in Friday's Orange Bowl. Read on for our top Tennessee-Clemson college football picks based on the best NCAAF odds.
The first New Year's Six Bowl takes place Friday night with the Volunteers set to battle the Tigers. Only five weeks ago, Tennessee (9-3 ATS, 7-5 O/U) hoped to compete in the College Football Playoff . A shocking loss at South Carolina in the penultimate regular season game derailed those hopes. The Volunteers did overwhelm in-state rival Vanderbilt the following game to secure a New Year's Six Bowl invite.
Clemson (7-6 ATS, 7-6 O/U) also didn't make the CFP despite running the table in league play. The Tigers lost to South Carolina one week after their Orange Bowl opponents but bounced back to dominate North Carolina in the ACC Championship Game. Clemson was the only ACC team to make a New Year's Six Bowl this year.
Here is our best Tennessee vs. Clemson Orange Bowl pick (odds via PointsBet; pick confidence based on a 1-to-5 star scale).
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