Monday Night Football has been a staple of the NFL season for years. NFL betting can be tricky in primetime games on Week 1.
This season, the Broncos and quarterback Russell Wilson will take on his former team, the Seahawks. The MNF spread is -6 for Denver, and the moneyline MNF odds are -250.
Some teams are traditionally better than others on Monday nights. Here's a look at NFL teams against the spread regarding Monday Night Football betting since 2003.
Teams With Best NFL ATS Record On Monday Night Football
| Team | ATS Record | Pct. |
| 49ers | 15-6-0 | 0.714 |
| Chiefs | 13-5-1 | 0.711 |
| Lions | 8-4-0 | 0.667 |
| Titans | 10-5-0 | 0.667 |
| Colts | 13-7-0 | 0.65 |
| Seahawks | 11-7-2 | 0.6 |
| Patriots | 15-10-1 | 0.596 |
| Bears | 16-11-0 | 0.593 |
| Eagles | 19-14-0 | 0.576 |
| Ravens | 14-11-0 | 0.56 |
| Giants | 15-13-1 | 0.534 |
| Chargers | 11-10-1 | 0.523 |
| Packers | 15-14-1 | 0.517 |
| Falcons | 10-10-0 | 0.5 |
| Bills | 5-5-2 | 0.5 |
| Panthers | 7-7-0 | 0.5 |
| Bengals | 7-7-0 | 0.5 |
| Rams | 9-9-1 | 0.5 |
| Steelers | 13-15-0 | 0.464 |
| Jets | 11-13-0 | 0.458 |
| Raiders | 8-10-1 | 0.447 |
| Cowboys | 10-13-0 | 0.435 |
| Jaguars | 3-4-0 | 0.429 |
| Saints | 12-17-0 | 0.414 |
| Buccaneers | 5-8-1 | 0.393 |
| Broncos | 9-15-2 | 0.385 |
| Dolphins | 7-12-0 | 0.368 |
| Browns | 4-7-0 | 0.364 |
| Vikings | 9-16-0 | 0.36 |
| Cardinals | 4-8-0 | 0.333 |
| Texans | 5-10-0 | 0.333 |
| Commanders | 7-17-0 | 0.292 |
NFL ATS records
The 49ers and Chiefs having the best ATS records with MNF betting should be of little surprise, especially recently.