TCU vs. Iowa State odds, line, spread: Proven model reveals college football picks, predictions for Week 13, 2022

A Big 12 battle is on tap between the No. 4 TCU Horned Frogs and the Iowa State Cyclones at 4 p.m. ET on Saturday at Amon G. Carter Stadium. TCU is hoping to wrap up a perfect regular season before playing in the Big 12 title game. The Horned Frogs are favored by 10 points in the latest TCU vs. Iowa State odds from Caesars Sportsbook, while the over/under is set at 47.5.'
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