SMU vs Louisville Prediction, Odds & Best Prop Bets – NCAAF, Week 6
SMU vs Louisville Prediction, Odds & Best Prop Bets – NCAAF, Week 6

The SMU Mustangs (4-1) visit L&N Federal Credit Union Stadium to take on the Louisville Cardinals (3-1) on Oct. 5 in Louisville, KY. Kickoff is scheduled for 12:00pm EDT.

Louisville is a betting favorite in Week 6, with the spread sitting at -7 (-110).

The SMU vs. Louisville Over/Under is 56.5 total points.

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SMU vs Louisville Prediction:

The winning team model predicts Louisville will win this game with 69.3% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both SMU and Louisville, key player performances this season and recent team trends.

SMU vs Louisville Spread Prediction:

Based on recent against-the-spread trends, the model predicts Louisville will cover the spread with 60.7% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


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  • SMU has hit the 1Q Game Total Over in 9 of their last 12 games (+5.45 Units / 40% ROI)
  • SMU has hit the 1H Game Total Under in 6 of their last 7 away games (+4.95 Units / 63% ROI)
  • SMU have covered the Spread in 7 of their last 12 games (+1.45 Units / 11% ROI)
  • SMU has hit the Moneyline in 6 of their last 7 away games (+0.90 Units / 1% ROI)
  • SMU have covered the 1Q Spread in 7 of their last 12 games (+0.85 Units / 5% ROI)
  • Louisville has hit the 1Q Moneyline in their last 6 games at home (+6.25 Units / 32% ROI)
  • Louisville has hit the 1H Moneyline in 6 of their last 7 games at home (+6.00 Units / 12% ROI)
  • Louisville have covered the 1Q Spread in 6 of their last 7 games at home (+5.15 Units / 67% ROI)
  • Louisville have covered the Spread in 6 of their last 8 games at home (+3.85 Units / 44% ROI)
  • Louisville has hit the Moneyline in 5 of their last 6 games at home (+3.10 Units / 12% ROI)

We’ve highlighted some favorite college football player prop bets for SMU players, looking at profitable historical betting trends:

Best SMU Player Prop Bets Today

  • Preston Stone has hit the Passing Yards Over in his last 2 games (+2.00 Units / 87% ROI)
  • Preston Stone has hit the Rushing Yards Over in his last 2 games (+2.00 Units / 85% ROI)
  • Preston Stone has hit the TD Passes Under in his last 2 games (+2.00 Units / 56% ROI)
  • Jake Bailey has hit the Receiving Yards Over in his last game (+1.00 Units / 95% ROI)
  • RJ Maryland has hit the Receiving Yards Under in his last game (+1.00 Units / 83% ROI)

Top NCAAF player prop bets for Louisville players, looking at profitable historical betting trends:

Best Louisville Player Prop Best Bets Today

  • no trends found

SMU Against the Spread (ATS) Record

SMU is 1-2 against the spread this college football season (-1.25 Units / -28.09% ROI).

  • SMU is 2-1 when betting on the Moneyline for -2.8 Units / -7.45% ROI
  • SMU is 1-2 when betting the Over for -1.2 Units / -27.27% ROI
  • SMU is 2-1 when betting the Under for +0.9 Units / 20.45% ROI

Louisville Against the Spread (ATS) Record

Louisville is 3-0 against the spread this college football season (+3 Units / 67.42% ROI).

  • Louisville is 1-0 when betting on the Moneyline for +1 Units / 22.47% ROI
  • Louisville is 2-1 when betting the Over for +0.9 Units / 20.45% ROI
  • Louisville is 1-2 when betting the Under for -1.2 Units / -27.27% ROI

SMU is 12-2 (.857) when intercepting at least 1 pass since the 2023 season– T-26th-best in FBS; Average: .682

SMU is undefeated (15-0) when scoring 22 or more points since the 2023 season– T-best in FBS; Average: .762

SMU is 5-1 (.833) when in a one score game since the 2023 season– 6th-best among Power Conference Teams; Average: .535

SMU is 9-2 (.818) when committing less than 60 yards in penalties since the 2023 season– T-11th-best among Power Conference Teams; Average: .603

Louisville is 11-3 (.786) when having a turnover margin within one of the opposing team since the 2023 season– T-19th-best in FBS; Average: .545

Louisville is 11-3 (.786) when averaging more than 5 yards on first down plays since the 2023 season– T-23rd-best in FBS; Average: .618

Louisville is 10-2 (.833) when intercepting at least 1 pass since the 2023 season– T-32nd-best in FBS; Average: .682

Louisville is 8-3 (.727) when the opposing team rushes more than 30 times since the 2023 season– T-17th-best in FBS; Average: .455

Louisville’s offense has thrown for 20 or more yards on 11.9% of 537 attempts since the 2023 season — T-34th-best among FBS offenses. SMU’s defense allowed 20+ yards on just 8.5% of attempts since the 2023 season — T-24th-worst among FBS defenses.

Louisville’s RBs has rushed for 2,987 yards on 490 carries (6.1 YPC) since the 2023 season — T-6th-best among FBS RBs. SMU’s defense have allowed just 4.0 YPC to RBs since the 2023 season — T-13th-best among FBS defenses.

  
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