College football is officially back, and we’ve got some interesting Week 0 action here as the Wyoming Cowboys battle the Illinois Fighting Illini. Both teams will be keen to kick things off with a win, and it will be interesting to see how Illinois perform after their rebuilding season in 2021. We have odds, best bets and picks for Wyoming vs Illinois right here, but make sure you also check out our College Football picks page, where we provide bets on the side and total for every game involving a Power 5 conference team.
Wyoming vs Illinois odds
Wyoming Cowboys'+420
Illinois Fighting Illini -540
Wyoming Cowboys -13.5 -110
Illinois Fighting Illini -13.5'-110