The San Francisco 49ers (7-3) and Seattle Seahawks (6-4) play on Thanksgiving night for a Week 12 matchup. Kickoff is scheduled for 8:20 p.m. ET (NBC). Below, we analyze FanDuel Sportsbook’s lines around the 49ers vs. Seahawks odds, and'make our expert NFL picks and predictions.
The 49ers are coming off a 27-14 victory against the Tampa Bay Buccaneers last Sunday, and it polished off the Jacksonville Jaguars 34-3 in the prior game as a 3-point favorite on the road. The Under has cashed in 2 straight, and 3 of the past 4 contests.
Against the NFC West, San Francisco is 2-0 straight up (SU) and 1-1 against the spread (ATS), cashing the Over in both divisional games.
The Seahawks are coming off a 17-16 loss against the Los Angeles Rams at SoFi Stadium, while losing 2 of the past 3 games overall. Seattle did cover the 1.5-point spread, snapping an 0-4-1 ATS slide. The Under has cashed in 5 of the past 7 games overall.