The San Francisco 49ers (3-4) and Los Angeles Rams (3-3) will square off in their 2nd meeting of the season Sunday afternoon. Kickoff between these two NFC West foes will be at 4:25 p.m. ET (FOX) from SoFi Stadium in Inglewood. Below, we analyze Tipico Sportsbook’s lines around the 49ers vs. Rams odds, and make our expert NFL picks and predictions.
The 49ers have been blown out in each of their last 2 games, dropping below .500. The Falcons beat them, 28-14, in Week 6 and the Chiefs dismantled their defense en route to a 44-23 victory last week. Now with RB Christian McCaffrey in the fold, the 49ers have one of the better skill groups in the NFL, and this will be the 2nd time in 3 weeks that McCaffrey faces the Rams defense; he did so in Week 6 with the Panthers. However, they must suit up without WR Deebo Samuel (hamstring) Sunday.
The Rams beat the Panthers in their last game before the Week 7 bye, improving their record to 3-3 after losing 2 straight games. They’re a half-game behind the Seahawks for the lead in the division, but it hasn’t been thanks to the offense, which ranks 29th in points per game this season. They’ll try to snap their 7-game regular-season losing streak to the 49ers this weekend.
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