San Francisco 49ers at Las Vegas Raiders odds, picks and predictions

The San Francisco 49ers and the Las Vegas Raiders open their preseasons against each other Sunday afternoon at Allegiant Stadium. Kickoff is scheduled for 4 p.m. ET (NFL Network). Below, we analyze BetMGM Sportsbook’s lines around the 49ers vs. Raiders odds, and'make our expert NFL picks and predictions.

These teams used to meet all the time when both were located in the Bay Area. This is the 1st preseason meeting since Aug. 29, 2021, when the 49ers thumped the Raiders 34-10 at Levi’s Stadium in Santa Clara as a 5.5-point favorite while the Over (36) cashed.

The 49ers and Raiders have been participating in joint practices in Nevada this week. QB Trey Lance will start for the 49ers as QB Brock Purdy is still recovering from the elbow injury he suffered in last season’s playoffs. QB Sam Darnold will also get some snaps

Former 49ers signal caller Jimmy Garoppolo is now the starter in Las Vegas, but he’ll only make a cameo, at best. Veteran backup QB Brian Hoyer also is likely to play little, if at all. Look for backup QBs Chase Garbers and Aidan O’Connell to get the longest looks, as they battle for the 3rd job.

  
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