The San Francisco 49ers (1-1) are on the road in Week 3 to face the Denver Broncos (1-1) for a Sunday Night Football matchup between two familiar foes — QBs Jimmy Garoppolo and Russell Wilson. Kickoff from Empower Field at Mile High is set for 8:20 p.m. ET (NBC). Below, we analyze Tipico Sportsbook’s lines around the 49ers vs. Broncos odds, and make our expert NFL picks and predictions.
The 49ers bounced back from their season-opening loss to the Chicago Bears with a 27-7 win over the Seattle Seahawks in Week 2. They lost QB Trey Lance'for the season with a broken ankle, so Garoppolo, who led the Niners to the NFC title game last season, returns to the starting lineup.
The Broncos lost17-16 to the Seahawks in Week 1. Denver had opportunities to win its opener but missed a potential game-winning 65-yard field goal and fumbled twice at the goal line. However, the Broncos bounced back in Week 2 as they defeated the Houston Texans 16-9. Their defense has held both opponents to under 260 yards of offense each week.
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