The San Francisco 49ers (2-2) and the Carolina Panthers (1-3) meet Sunday at Bank of America Stadium in Charlotte. Kickoff is scheduled for 4:05 p.m. ET (CBS). Below, we analyze Tipico Sportsbook’s lines around the 49ers vs. Panthers odds, and make our expert NFL picks and predictions.
The 49ers pasted the Rams 24-9, using their top-ranked defense to confuse and frustrate the defending champs all game long.
San Francisco ranks No. 1 with just 234.5 total yards allowed and 11.5 points allowed per game, while ranking No. 2 with 161.3 passing yards allowed and 73.3 rushing yards allowed per game.
The Panthers offense ranks dead-last in total yards per game with 262.3, and facing the 49ers’ top-ranked D isn’t the cure for their ills. Carolina is averaging just 19.5 PPG, ranking 17th in the NFL, and 2 of the team’s 4 touchdowns in the past 2 games have come on defensive scores.