The San Francisco 49ers begin the long road back to the postseason, handing the keys to the offense to second-year quarterback Trey Lance. The third overall selection in the 2021 draft, Lance is talented and, with a bevy of playmakers surrounding him, could make the big step forward that is demanded of him if the 49ers are to return to the NFC Championship Game, where they suffered a heartbreaking loss to the eventual Super Bowl champion Los Angeles Rams.
This year’s schedule has San Francisco facing the high-flying AFC West Division and NFC South, in addition to the home-and-home series with its traditional NFC West rivals. This is not an easy trek – overall, the Niners’ schedule is ranked fifth-hardest based on opponents’ 2021 win/loss percentage. Can they exceed their NFL win total of 10.5 (+115) at the online sportsbook?
Trey Lance's time is now pic.twitter.com/Yfgq1MUTa8
— PFF (@PFF) July 26, 2022
Determined to build on the foundational success of last season, here is a closer look at the road ahead for San Francisco in 2022.
Week 1 @ Chicago Bears
Date: Sunday, September 11
Time: 1:00 p.m. ET
The 49ers open their season as solid favorites to handle the rebuilding Bears. I
n his rookie season, Chicago quarterback Justin Fields experienced some trying but valuable growing pains. However, facing San Francisco’s swarming defense, he has a mountain to climb. The Niners rallied with 18 fourth-quarter points to defeat the Bears 33-22 at Soldier Field last season.
Week 2 vs. Seattle Seahawks
Date: Sunday, September 18
Time: 4:05 p.m. ET
San Francisco may be at the top of the list of teams glad to see Russell Wilson head to Denver.
The Seahawks swept the 49ers in their home-and-home last season, with Wilson accounting for five touchdowns over the two games.
Week 3 @ Denver Broncos
Date: Sunday, September 25
Time: 8:20 p.m. ET
As relieved as the 49ers maybe not to have to face Russell Wilson at quarterback for the Seahawks, they can’t avoid him altogether, meeting their nemesis in his new backyard.
Week 4 vs. Los Angeles Rams
Date: Monday, October 3
Time: 8:15 p.m. ET
An NFC Conference Championship rematch on Monday Night Football – one of the most anticipated matchups of the young season.
San Francisco will be out to avenge the bitter defeat that saw the 49ers give up a ten-point fourth-quarter lead, costing Kyle Shanahan and company a trip to the Super Bowl. The Niners won both regular season matchups, including a thrilling 27-24 overtime victory in Week 18 to clinch a playoff berth.
Week 5 @ Carolina Panthers
Date: Sunday, October 9
Time: 4:05 p.m. ET
Any assessment of how difficult facing the Panthers will be at any given point in the schedule begins and ends with the health of running back Christian McCaffrey.
Assuming he is good to go, with the addition of former Browns quarterback Baker Mayfield, the Panthers bring a more formidable attack to this matchup – an opponent that the 49ers cannot take lightly.
Week 6 @ Atlanta Falcons
Date: Sunday, October 16
Time: 1:00 p.m. ET
With legendary quarterback Matt Ryan in Indianapolis, the Falcons enter a new era looking to rebuild. San Francisco is unlikely to let this one get away.
Best teams against the spread this season:
Cowboys 13-5 ATS
Bengals 14-7 ATS
Packers 12-6 ATS
Lions 11-6 ATS
49ers 12-8 ATS
Colts 10-7 ATS
Bills 10-7-2 ATSWorst teams: