The San Diego Padres (66-75) and Houston Astros (80-61) open up a 3-game set at Minute Maid Park Friday. First pitch is at 8:10 p.m. ET (Apple TV+). Let’s analyze BetMGM Sportsbook’s lines around the Padres vs. Astros odds and make our expert MLB picks and predictions for the best bets.
Season series: First meeting Padres won 4 of 6 games in 2021
After an off day Thursday, the Friars head into Houston after dropping 2 of 3 to the Philadelphia Phillies to start the week. San Diego is just 11-19 over the last 30 games and sits 7 games out of an NL Wild Card spot. However, the Padres have had success in interleague play, going 21-16.
The Astros are fresh off a 3-game sweep of the fading Texas Rangers from Monday to Wednesday. Houston is 7-3 over the last 10 games and holds a half-game lead over the Seattle Mariners in the AL West. The Astros are 23-17 in interleague play.